Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6
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منابع مشابه
Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6.
Atopic dermatitis (AD) is characterized by a defective skin barrier which allows increased allergen and pathogen penetration. Loricrin (LOR) and involucrin (IVL) are proteins important for skin barrier formation and integrity. In this study, we demonstrate that the gene and protein expression of LOR and IVL is significantly decreased in involved (LOR: p<0.001; IVL: p<0.001) and uninvolved (LOR:...
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134 Ann Dermatol Received November 29, 2012, Revised March 6, 2013, Accepted for publication March 25, 2013 Corresponding author: Weon Ju Lee, Department of Dermatology, Kyungpook National University School of Medicine, 200 Dongduk-ro, Jung-gu, Daegu 700-721, Korea. Tel: 82-53-420-5838, Fax: 82-53426-0770, E-mail: [email protected] This is an Open Access article distributed under the terms of th...
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ژورنال
عنوان ژورنال: Clinical Immunology
سال: 2008
ISSN: 1521-6616
DOI: 10.1016/j.clim.2007.11.006